The role of vitamin D in a systemic approach to enhancing endodontic treatment

In contemporary endodontics, it is becoming increasingly clear that even technically perfect local interventions do not ensure predictable healing of periapical tissues. The outcome of treatment significantly depends on the patient's systemic condition, including vitamin D status and bone metabolism. This study provides a comprehensive analysis of international and Russian data on the role of vitamin D in regulating bone remodeling, immune response, and antimicrobial defense. It also examines the impact of vitamin D on the rate and extent of repair of periapical lesions following endodontic treatment. The research demonstrates that maintaining an optimal level of 25(OH)D is associated with a faster reduction in areas of destruction, particularly in patients with osteopenia and other risk factors for bone metabolism disorders. The paper discusses international guidelines for diagnosing and correcting vitamin D deficiency, as well as Russian experience with oral forms of cholecalciferol, including the domestic Osteo-Vit D3 complex. It proposes a systematic clinical algorithm for integrating the assessment and correction of vitamin D status into endodontic practice as a complement to standard protocols for root canal treatment and obturation.