Differences of Coagulation and Fibrinolysis Profiles in Controlled and Uncontrolled T2DM Patients

Background: Type 2 diabetes mellitus (T2DM) is one of the degenerative diseases that continues to increase. Diabetes is one of the three biggest causes of death in Indonesia in 2017. This burden is exacerbated by the presence of uncontrolled diabetes cases, which have a negative impact on almost every system of the human body. Coagulopathy, which is defined as a disorder of the blood clotting process, is one of the clinical manifestations of uncontrolled T2DM. Chronic hyperglycemia in T2DM can affect the hypercoagulation process which includes changes in platelet activation time, endothelial cell function, and fibrinolysis. Objective: To determine and analyze the differences in coagulation and fibrinolysis profiles of controlled and uncontrolled T2DM patients. Method: The design of this study was cross-sectional with a target population of adult T2DM patients at the Diponegoro National Hospital in Semarang City. Data collection on respondents includes filling out questionnaires and taking blood samples to examine the coagulation and fibrinolysis profiles and Hba1C levels of respondents Results: There were no abnormalities in prothrombin time (PT) and activated partial prothrombin time (APTT) values in the two groups of this study and there was also no difference in the mean values of PT and APTT between the two groups in this study. Increased D-dimer concentrations occurred in both groups but there was no significant difference between the two groups (p > 0.05). Conclusion: There was no significant difference in PT, APTT, and D-dimer values in the two groups of the study.