From Ostrich to Mouse to Human: Translation of the Functional Liver PET Tracer [ 68 Ga]Ga-TEoS-DAZA

Journal of Nuclear Medicine 2026

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Authors: Julia Greiser, Robert Drescher, Mitali Sonawane, Christian Kuehnel, Steffen Wiegand, Olga Perkas, Marta Pomraenke, Thomas Winkens, Mari Teuter, Silav Al-Bazaz, TL Ross, Jens P. Bankstahl
+4 more Frank Michael Bengel, Adrian Tibor Press, Michael S. Bauer, Martin Freesmeyer
DOI: 10.2967/jnumed.125.271020
Cited by: 1
References: 40

Abstract

Ga]Ga-TEoS-DAZA was shown to be a suitable hepatobiliary tracer using both mice and ostrich embryos as preclinical models; however, there were limits in translatability in both models because of a distinctly faster hepatic uptake and biliary excretion (mice) or a slower biliary excretion (ostrich embryo) compared with that in the human.

Fields of Study & Subjects

Peptidase Inhibition and Analysis Radiopharmaceutical Chemistry and Applications Medical Imaging Techniques and Applications

Publication details

Journal / source
Journal of Nuclear Medicine
Publisher
Society of Nuclear Medicine
Volume
67
Issue
4
Pages
615–620
Publication date
29 January 2026
Language
EN