Effects of ethanol fruit rind extract of Nephelium lappaceum on hematological indices, blood glucose, body and organ weights of alloxan-induced diabetic albino Wistar rats.

The study investigated the effect of ethanolic fruit rind extract of Nephelium lappaceum on blood glucose, body and organ weights, and hematological indices in alloxan-induced diabetic albino Wistar rats. Sixty male albino Wistar rats weighing between 116 and 231 g were randomly assigned to six groups of ten rats in each group. Groups 1-5 rats were induced with 150 mg/kg body weight of alloxan monohydrate intraperitoneally. Fasting blood glucose was measured four days after induction; rats with blood glucose levels of 200 mg/kg and above were considered diabetic. Group 4 was treated with 50 mg/kg body weight of metformin. Group 5 was the diabetic untreated group that equally had alloxan, and group 6 was the normal control group. Group 1-3 were treated with 500, 1000, and 1,500 mg/kg body weight of extract, respectively, for 28days. Glucose levels were checked weekly using a glucometer. Rats treated with Nephelium kappacism peel extract showed a dose-dependent decrease in glucose levels when compared to the untreated diabetic group. The result of the study also revealed a significant reduction (p