Anti-Hyperglycemic Activity of Urtica dioica Extract in Obese Male Sprague Dawley Rats: Evaluation of HOMA-IR and HOMA-β

Obesity is characterized by adipocyte accumulation that impairs glucose uptake, leading to insulin resistance, hyperglycemia, and an increased risk of diabetes mellitus. Given the limitations and adverse effects of pharmacological therapies for diabetes, alternative agents are needed. Urtica dioica contains flavonoids with anti-inflammatory and antioxidant properties that may improve glucose homeostasis. This experimental study employed a pre-test and post-test control group design using 25 male Sprague Dawley rats divided into five groups: healthy control (K1), obese control (K2), and three obese groups receiving Urtica dioica extract at doses of 125, 250, and 500 mg/kgBW (D1–D3) for four weeks. Data were analyzed using one-way ANOVA and paired t-test. Administration of Urtica dioica extract at 500 mg/kgBW (D3) significantly reduced blood glucose (79.90 ± 2.51 vs. 177.92 ± 3.30; p