Quantitative Electroencephalography Analysis in Panic Disorder: Exploring the Neurophysiological Significance of High Beta Activity

Psychiatry Investigation 2026 Open access

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Authors: Chang Hoon Park, Jun-Young Lee, Hee Yeon Jung, Seok-Im Lee, Sohee Oh, Jung-Seok Choi, Joon Hwan Jang, So Young Yoo
DOI: 10.30773/pi.2025.0141
Cited by: 1
References: 45

Abstract

OBJECTIVE: This study aimed to investigate the neurophysiological characteristics of panic disorder (PD) by analyzing quantitative electroencephalography (QEEG) data, with a particular focus on high beta activity. METHODS: In this retrospective study, resting-state QEEG data from 58 patients with PD and 23 healthy controls (HC) were analyzed. Spectral power was calculated for delta (1-4 Hz), theta (4-8 Hz), alpha (8-12 Hz), beta (12-25 Hz), and high beta (25-30 Hz) bands across frontal, central, and posterior regions. Group differences were assessed using generalized estimating equations, and Pearson correlation analyses were conducted to examine associations between electroencephalography activity and clinical symptoms. RESULTS: PD patients showed significantly higher high beta power across all regions compared to HC (frontal: estimate=1.276, χ²=12.48, p

Fields of Study & Subjects

Anxiety Depression Psychometrics Treatment Cognitive Processes Posttraumatic Stress Disorder Research Neural and Behavioral Psychology Studies

Publication details

Journal / source
Psychiatry Investigation
Publisher
Korean Neuropsychiatric Association
Volume
23
Issue
2
Pages
270–277
Publication date
3 February 2026
Language
EN