Comparative Antitumor and Mechanistic Effects of the Iodine–Lithium Complex KC-144 in Cisplatin-Sensitive, Cisplatin-Resistant and Non-Malignant Mesothelial Cells

Engineered Science 2026 Open access

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Authors: Аssima О. Abekova, Roza Kenzhebekova, Ardak B. Jumagaziyeva, Seitzhan Turganbay, Аlexander Ilin, S. Ossikbayeva, Aida Kydyrbekova, Rinat Islamov
DOI: 10.30919/es2033
Cited by: 0

Abstract

KC-144, an iodine–lithium complex, counters cisplatin resistance in PM by tipping mitochondrial redox balance, triggering Δψm loss, ROS rise, G0/G1 shift, and strong suppression of clonogenic survival.

Fields of Study & Subjects

Metal complexes synthesis and properties Cell death mechanisms and regulation Bioactive Compounds and Antitumor Agents

Publication details

Journal / source
Engineered Science
Publication date
1 January 2026
Language
EN