Supramolecular Co-Amorphous Quercetin-Piperine Microspheres for Enhanced Bioaccessibility and Synergistic Neuroprotection

Engineered Science 2026 Open access

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Authors: Zibin B. Zou, Qiuru Tan, Jiao Wang, Zhi Dong, Shuang Tian, Qinglin Huang, Chen Liu, Wenping Wang
DOI: 10.30919/es2132
Cited by: 0

Abstract

The poor aqueous solubility and low bioavailability of natural nutraceuticals, such as quercetin (QUE) and piperine (PIP), limit their healthcare efficacy on Alzheimer's disease (AD).This study developed carrier-free co-amorphous microspheres (CAM-MPs) of QUE and PIP via solvent co-evaporation to address these challenges.Supramolecular interactions (hydrogen bonding, van der Waals forces)

Fields of Study & Subjects

Drug Solubulity and Delivery Systems Advanced Drug Delivery Systems Nanoparticle-Based Drug Delivery

Publication details

Journal / source
Engineered Science
Publication date
1 January 2026
Language
EN