Green Tea Reduces TNF-Alpha and IL-6 Inflammatory Cytokines Induced by Ethyl Alcohol Toxication in Rats

Objective: Studies investigating the antioxidant and anti-inflammatory effects of green tea (GT) on liver tissue are limited in number. This study aims to reveal the therapeutic mechanisms through which green tea modulates the inflammatory and oxidative stress responses caused by ethyl alcohol (EA) toxicity. Methods: The 28 Wistar albino rats used in our study were randomly selected and divided into four equal groups. Group I: Control, Group II: GT group, administered for 7 days instead of drinking water. Group III: EA group, administered subcutaneously at a daily dose of 5 g/kg for 7 days. Group IV: EA+GT group, 5 g/kg EA was administered daily for 7 days and the next day, the rats were given GT instead of drinking water for 7 days. Results: Increased AST, ALT, TOS, and MDA values with the EA application showed a significant decrease in the EA+GT group. Positive signals of TNF-α and IL-6 cytokines decreased in the EA+GT group. In addition, pathological findings such as degeneration and dilatation in tissues belonging to the EA group were replaced by regenerative changes in the EA+GT group. Conclusion: EA toxicity has been associated with increased oxidative stress levels and inflammatory cytokine release. In contrast, GT's anti-inflammatory and antioxidant properties suggest it may be a potential therapeutic agent against hepatotoxicity.