Comparative production trials of combined micronized dosage forms based on benzimidazoles and niclosamide against bothriocephalosis in carp

The purpose of the research is a comparative production trial of combined micronized dosage forms based on benzimidazoles and niclosamide against bothriocephalosis in carp. Materials and methods . A formulation was previously developed for two dosage forms based on albendazole with niclosamide and fenbendazole with niclosamide. Laboratory batches of therapeutic feeds containing combined micronized dosage forms were produced, and the Bothriocephalus infection rate in fish in the growing season and the efficacy of the combined micronized dosage forms against bothriocephalosis in carp were determined using common methods. The efficacy was assessed for the combined micronized dosage forms under production conditions. Results and discussion. A comparative production test of two combined micronized dosage forms as part of therapeutic granulated feed against bothriocephalosis in carp found the therapeutic feed containing a 4% combined micronized dosage form based on albendazole and niclosamide to be the most effective if administered once at the 5% feeding dose. This dosage form demonstrated efficacy similar to that of the standard drug (Microsal), which is currently used to treat bothriocephalosis in carp.