FORMULATION AND EVALUATION OF ANTIEMETIC DRUG LOADED LOLLIPOP FOR PAEDIATRIC USE

The medicated lollipops are flavoured mediated dosage forms which are intended to be sucked or held on the mouth or pharynx containing one or more medicaments usually in a sweetened base.The Antiemetic lollipop (AEL) prepared with DOM is a good and attractive formulation for the paediatric use.It is very effective during travelling for those who have motion sickness and also for other conditions.To improve the bioavailability, the drug was made as QIC with βCD, CA and mannitol in two different ways named physical mixture and kneaded complex.Out of this, KC with equimolar concentration of DM, βCD, CA and mannitol is found to be highly water soluble than the other complexes.This is why because of the conversion of the crystalline character of the DM to amorphous through the formation of QIC and its confirmed through solubility, FTIR, PXRD studies.This QIC is used for the development of AEL.Ten formulations were prepared using different concentrations of excipients.F1 was formulated with DM and the F2-F10 with QIC.All formulations were evaluated through different parameters and finally found that F9 prepared with methyl cellulose and glycerine as polymer and plasticizer respectively provides the best result of assay, in vitro dissolution and other parameters also provide good result.Hence F9 is found to be the optimum formulation and it was further used for the stability studies.Finally after the completion of the stability study it was concluded that the optimum formulation of AEL is sterile and stable over shelf life.