SYNTHEISIS OF HYBRID BENZIMIDAZOLE AND PYRAZOLE DERIVATIVES AND THEIR PHARMACOLOGICAL EVALUTION

Prominent biological activities of benzimidazole and pyrazole compounds include antibacterial, antiviral, antitumor, analgesic, anti-inflammatory, anti-Alzheimer's, anti-ulcer, and antidiabetic effects.Hence Pyrazole substituted Benzimidazole derivatives were synthesised and evaluated for their antimicrobial, antifungal and antitubercular activity.Of the two synthesised compounds, bromo substituted derivatives has better antifungal activity when compared with chloro substituted derivatives.Both the compounds showed mild to moderate anti-tubercular activity against H37RV strain of Mycobacterium tuberculosis using Pyrazinamide, Ciprofloxacin and Streptomycin as standard.