OPTIMIZATION AND FORMULATION OF N-ACETYLCYSTEINE PELLETS: A COMPREHENSIVE STUDY

This investigation explores the development of N-acetylcysteine (NAC) pellets, aiming to enhance drug absorption in the gastrointestinal tract.NAC disrupts sulfide bonds in mucoproteins, easing airway clearance.Despite NAC's versatility and market growth, pellet form is currently unavailable.NAC pellets were designed via a two-factor optimization approach, analyzing drug content, Invitro Dissolution studies and Invitro drug release quantitatively.Visual representations aided in understanding variable impacts.Formulated through extrusion and spheronization, pellets underwent various evaluations, revealing firstorder kinetics with strong linearity and Fickian diffusion mechanism.This research advances NAC pellet formulation and optimization, promising enhanced drug delivery and therapeutic efficacy.