METABOLIC SYNDROME AND THERAPEUTIC EFFECTS OF UNANI PHARMACOPOEIAL HERBAL DRUGS IN ITS MANAGEMENT: A SYSTEMATIC REVIEW

IntroductionMetabolic syndrome is a multi-faceted global health challenge characterized by a cluster of interconnected risk factors that increase the likelihood of cardiovascular diseases, diabetes, and related disorders.This systematic review critically evaluates the existing literature on the therapeutic effects and possible mechanism of action of Unani single drugs, Darchini (Cinnamomum Zeylanicum), Hulba (Trigonella foenum), and Jaiphal (Myristica fragrans) in managing various components of metabolic syndrome, such as obesity, insulin resistance, dyslipidemia, and hypertension. Results:The findings indicate that Darchini, Hulba, and Jaiphal, either individually or in combination, exhibit promising anti-inflammatory, antioxidant, hypolipidemic, and hypoglycemic properties.These herbs were found to improve insulin sensitivity, lipid metabolism, reduce adiposity, and help regulate blood pressure.The review also highlights the potential mechanisms of action, which include the modulation of insulin signalling pathways, adipokine secretion, and lipid metabolism.