Analysis of Factors Influencing Subjective Well-Being in Young and Middle-Aged Patients Undergoing Maintenance Hemodialysis

Aims/Background: Young and middle-aged patients undergoing maintenance hemodialysis (MHD) experience significant physical impairment and psychological stress, resulting in reduced levels of subjective well-being. Therefore, this study aimed to assess the subjective well-being of this population and to identify its influencing factors, thereby informing the clinical development of targeted nursing strategies. Methods: Clinical data were collected from 220 young and middle-aged MHD patients at the Blood Purification Center of the Second Affiliated Hospital, Zhejiang University School of Medicine between April 2024 and April 2025. General demographic and clinical characteristics, along with scores from relevant assessment scales, were collected. The factors influencing subjective well-being were analyzed in this patient cohort. Results: The mean General Well-Being (GWB) scale score among these patients was 62.44 ± 3.12. Statistically significant differences were observed across education level, per capita monthly family income, self-care ability, self-management ability, symptom distress, financial burden to the family, and social support (p < 0.05). Multiple linear regression analysis indicated that education, per capita monthly family income, self-care ability, self-management ability, symptom distress, financial burden on the family, and social support were significant predictors of subjective well-being among young and middle-aged MHD patients (p < 0.05). Conclusion: The subjective well-being of young and middle-aged MHD patients remains at a moderate level and is influenced by factors such as education level, per capita monthly family income, self-care ability, self-management ability, symptom distress, financial burden on the family, and social support. Nursing care interventions should be designed and implemented based on these factors to improve the overall well-being of this patient group.