Progress in Bioengineering: An Extensive Examination of State-of-the-Art Innovations in the Development of Artificial Corneas

Frontiers in Bioscience-Elite 2026 Open access

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Authors: Marco Zeppieri, Caterina Gagliano, Fabiana D’Esposito, Mutali Musa, Andrea Russo, Antonio Longo, Rosa Giglio, Daniele Tognetto, Davide Scollo, Federico Visalli
DOI: 10.31083/fbe38592
Cited by: 1
References: 56

Abstract

Artificial corneas represent a significant breakthrough in addressing global corneal blindness, impacting millions of individuals worldwide. The scarcity of donor tissue and the complications of immune rejection necessitate the development of synthetic alternatives. This review examines key innovations in biomaterials, scaffold design, and regenerative medicine that have informed the development of artificial corneas. Recent studies have demonstrated that polyethylene glycol (PEG)-based hydrogels exhibit 98% light transmittance and an elastic modulus of 1.5 MPa, whereas collagen scaffolds achieve 85% clinical success with

Fields of Study & Subjects

Corneal Surgery and Treatments Graphene and Nanomaterials Applications Wound Healing and Treatments

Publication details

Journal / source
Frontiers in Bioscience-Elite
Publisher
IMR Press
Volume
18
Issue
1
Pages
38592–38592
Publication date
10 March 2026
Language
EN