Oral microbiota and gastroenterological diseases: a hypothetical “journey” of the periodontal microbiota on the “periodontal-gastroenterological express” along the route mouth-intestine

Research and publications over the past decade have radically changed traditional medical concepts and our understanding of the possible relationship between organs and body systems. So, many studies are devoted to the study of the relationship between the intestinal microbiome and various diseases. The microbiome of the oral cavity has a certain effect on the intestinal microbiome. This review, based on published sources from the Pubmed and Scopus databases, which examined the relationship between periodontal microbiota/periodontal diseases and gastroenterological diseases, presents an expanded version of the report at the round table of the Scientific Society of Gastroenterologists of Russia on June 20, 2025. Within the framework of the hypothetical “journey” of the periodontal microbiota on the “periodontal-gastroenterological express” along the route mouth-intestine, the possible influence of the periodontal microbiota and periodontal diseases on the development of gastroenterological diseases is considered. The results of epidemiological, experimental and clinical studies indicate that periodontopathic bacteria can participate in the development of cancer of the gastrointestinal tract, peptic ulcer, inflammatory bowel disease and non-alcoholic fatty liver disease.