Helicobacter pylori and fungal-protozoal infections

Chronic gastroduodenitis (CGD) is considered as a multifactorial pathology, in the etiology of which the leading role is assigned to infection with H. pylori (HP). The issue of symbiotic relationships of HP with other infectious agents, including pathogens of parasitic and fungal nature, is being discussed in the scientific community, but the features of combined lesions are insufficiently described. The aim of the study was to study the frequency of H. pylori and protozoal fungal invasions in chronic inflammatory diseases of the stomach and duodenum, the effect on morphological changes in the mucous membranes of the gastrointestinal tract. Material and methods. 87 patients diagnosed with CGD were examined. The material for the study was biopsies of the gastric mucosa and duodenum 12, faeces. Cytological and immunochromatographic methods were used to identify HP. The staining by Romanovsky-Giemsa was used for detection of the morphological changes in the mucous membranes and the microflora. Parasitoscopic methods were used to identify the protozoa. The results of the study. When studying the microbial composition of the stomach in 87 patients with CGD, the mixed microflora was found, including eukaryotic nature. A preliminary analysis of the results in the group of H. pylori-positive patients (n=57) showed that the association of H. pylori and yeast-like fungi of the genus Candida was found in 29% of cases, the association of H. pylori, yeast-like fungi of the genus Candida and protozoa (G. lamblia) - in 19% of cases. The study of the SOF microflora of patients with CGD showed the presence of more severe forms of morphological changes, in particular, intestinal metaplasia and dysplasia, in H. pylori and fungal-protozoal mixed invasion, than in the absence of infection (p