Inflammatory markers and endothelial dysfunction markers in patients with inflammatory bowel disease

In patients with IBD the most sensitive markers of ED are VCAM-1, ICAM-1 and vWF, whose levels increase during the active phase and decrease during remission. CRP shows a stable correlation with Crohn’s disease activity, but is less predictive in ulcerative colitis. Levels of ET-1 in IBD remain relatively unchanged; however, changes are observed in experimental models of colitis and in chronic uveitis. ADMA shows ambiguous results in IBD but is elevated in isolated uveitis manifestations, indicating systemic inflammation even in clinically localized lesions.