Postprandial distress syndrome: mechanisms of development, diagnosis and treatment

The article presents a literature review of modern Russian and foreign publications devoted to the study of prevalence, pathogenetic mechanisms, diagnostics and treatment of postprandial distress syndrome. It is shown that this variant of functional dyspepsia is the most common. In its pathogenesis, the leading role belongs to disorders of relaxation accommodation of the proximal stomach. Existing diagnostic criteria for functional dyspepsia variants are based on anamnestic data, which does not allow for their clear verification. For the purpose of differential diagnostics of functional dyspepsia, along with endoscopic examination, it is advisable to clarify the disorders of gastroduodenal motility and the profile of intestinal peptides regulating it. Modern approaches to the treatment of patients with postprandial distress syndrome include the use of prokinetics and neuromodulators against the background of diet therapy and non-drug correction.