Trimethylamine- N-oxide (TMAO) in the pathogenesis of rheumatoid arthritis and cardiovascular complications
Abstract
Rheumatoid arthritis is a multifactorial autoimmune disorder characterized primarily by chronic inflammation and destruction of joint tissues. In recent years, the gut microbiome and its metabolites have played a key role in its pathogenesis, among which trimethylamine N-oxide (TMAO) attracts particular attention. The gut microbiota - a complex ecosystem of many microorganisms and their metabolic products - performs a crucial function in regulating immune balance. Disruption of its composition (dysbiosis) is associated with a wide range of autoimmune diseases, including rheumatoid arthritis.
Fields of Study & Subjects
Gut microbiota and health
Rheumatoid Arthritis Research and Therapies
Gout
Hyperuricemia
Uric Acid
Publication details
- Journal / source
- Экспериментальная и клиническая гастроэнтерология
- Issue
- 12
- Pages
- 127–134
- Publication date
- 26 February 2026
- Language
- EN