Investigation of the effect of Coxsackieviruse B (CVB), Herpes simplex virus 1 (HSV1), and Parvovirus(B19), in patients with insulin-dependent diabetes mellitus

Insulin-dependent diabetes mellitus (T1DM) is an autoimmune condition thought to arise from environmental exposures in genetically predisposed individuals. Enteroviruses have frequently been proposed as key candidates in triggering the disease. However, the current body of literature presents conflicting findings concerning the relationship between viral infections and T1DM, in addition to uncertainties surrounding first-line antiviral strategies for protective immunity The direct of this study was to examine the currency of three viruses which can cause dogged infections Coxsackievirus (B4), herpes simplex virus type1 (HSV-1), and parvovirus (B19) in patients with T1DM. Our study involved 68 T1DM patients and 24 healthy individuals as a control group. Blood was taken from all the study participants. Methodological considerations of the ELISA technique were used to measure virus antibodies. In general, our results showed that only CVB4 has a role in the development of T1DM patients. However B19 virus is useful in distinguishing between DM1 and LADA types, as well as between children and adults with T1DM disease, while no role for HSV-1 in T1DM patients.