EFFECTS OF RESVERATROL ON ENDOTHELIAL FUNCTION IN RESISTANCE TRAINED MALES

https://youtu.be/Bn9UOv-IlFo BACKGROUND: Resveratrol (RES), a polyphenol with antioxidant and anti-inflammatory properties, has been investigated for potential cardiovascular (CV) benefits via improved endothelial function. Flow-mediated dilation (FMD), the criterion non-invasive assessment of vascular reactivity, has been utilized as a risk evaluation tool due to its sensitivity in predicting future CV events. Despite the observed benefits of RES supplementation in at-risk populations, the cardioprotective effects in physically active individuals are controversial. RES supplementation may neutralize the exercise-induced adaptations reliant on transient oxidative stress. While resistance training (RT) has been shown to improve vascular health, it remains unclear whether concurrent RES use is beneficial, benign, or detrimental in this population. Therefore, the purpose of this investigation was to examine the effects of a novel cold-water dispersible RES supplement on endothelial function in physically active RT males. METHODS: Nineteen RT males (20.7±1.4 yrs, 26.9±3.8 kg/m 2 ) completed a randomized, double-blind, placebo-controlled, crossover study. All participants met the American College of Sports Medicine (ACSM) recommendations of at least 150 minutes of moderate-intensity aerobic activity and twice weekly muscle-strengthening activities targeting all major muscle groups, for at least six months. Participants were randomized in a counter-balanced fashion to consume RES (500 mg·d⁻ 1 ) or placebo (PLA) for 14 days, separated by an 18-day washout. Brachial artery FMD assessments were completed at baseline and after each supplementation period. Standardization of FMD procedures was conducted following established guidelines. Outcome variables included changes in FMD percentage (FMD%), shear area-under-the-curve (AUC), and normalized FMD to shear AUC (FMD-AUC). Data were analyzed via repeated measures analysis of variance (ANOVA). Statistical significance was set at p