THE DYNAMIC RELATIONSHIP BETWEEN PHYSICAL ACTIVITY AND SYMPTOMS IN CML PATIENTS

https://youtu.be/E1PuUmQVfyg INTRODUCTION: Advancements in treatment for chronic myeloid leukemia (CML), which is anticipated to become the most prevalent type of myeloid neoplasm in the next several decades, have resulted in improved outcomes for patients. Tyrosine kinase inhibitors (TKIs), the standard of care for CML, promote longevity, yet patients report significant fatigue. Consequently, patients demonstrate marked reduction in physical functioning and reduced quality of life. Physical activity (PA) has been shown to be an effective, non-pharmacological approach to reducing or managing fatigue symptoms among cancer populations. Despite this, data indicates that cancer survivors are not meeting the PA guidelines. Further, evidence indicates that patients with CML experiencing fatigue-related symptoms from TKIs engage in one hour less of daily PA compared to non-fatigued CML patients. The purpose of this study was to investigate and characterize the between- and within-person temporal associations among PA and symptom burden throughout the day in patients with CML. METHODS: 48 patients with CML were recruited for this study. Upon consent, patients provided demographic and health history information. Patients completed a 7-day PA monitoring period wearing a waist-mounted actigraph GT9X accelerometer. Concurrently, an ecological momentary assessment (EMA) questionnaire was randomly administered four times each day to assess fatigue and pain symptoms. PA data were classified according to sedentary behavior (SB), light intensity PA (LPA), moderate and vigorous intensity (MVPA). Mixed models assessed the bidirectional, between-person (BP) and within-person (WP) associations of current day symptoms with minutes of PA each day. RESULTS: Participants were, on average, 52±14 years old, 50% female, mostly white (95%), and had an average BMI of 31 kg.m-2. The average time since diagnosis was 6 years, 8 months, average length of TKI usage was 6 years, 6 months, and the average PROMIS fatigue T-score was 58±9.7. WP associations were significant for fatigue, pain symptoms, and MVPA such that participants reported higher than their average symptom rating on a given day and spent 3 min less time in MVPA (p