Sepsis: Avances en biomarcadores, predictores y tratamiento de la coagulación intravascular diseminada

Introduction: sepsis can be defined as an excessive inflammatory response leading to multisystem failure, being one of the causes of disseminated intravascular coagulation (DIC). Discussion remains on the use of one of the various proposed DIC diagnostic scales, including the International Society on Thrombosis and Hemostasis DIC Score and Japanese Association for Acute Medicine score. Current studies are likely to measure other types of markers such as the TAT complex, prothrombin fragments 1+2, PAI-1 expression and C reactive protein, for a more accurate diagnosis. Objective: to analyze the latest biomarkers and predictors reported in patients with sepsis-associated disseminated intravascular coagulation. Methods: a literature review in scientific databases, including articles published in the last 5 years, was performed. Conclusion: the diagnosis and prediction of DIC induced by some conditions such as sepsis, are still uncertain due to the sensitivity of many of the abovementioned tests. Regarding treatment, there is increased evidence of the need to propose combination therapy.