Comportamiento mitocondrial en enfermedades cardíacas

Introduction: as mitochondria play a central role in ATP production, they are related to cardiovascular diseases, the leading cause of death worldwide. Objective: to describe mitochondrial behavior in cardiovascular diseases. Discussion: mitochondrial dysfunction is accountable in cardiovascular conditions. ATP production is impaired in ischemia/reperfusion injury increasing oxidative stress; oxidative phosphorylation efficiency is reduced in heart failure exacerbating energetic deficiency; in valvular heart disease, dysregulation of mitochondrial homeostasis affects valvular function; and ionic imbalances and intracellular signaling alterations are associated with mitochondrial dysfunction in arrhythmias. Conclusion: cardiovascular diseases share similarities in bioenergetic and molecular alterations, underscoring the importance of understanding the role of mitochondria in this context.