Prevalence of TERT Promoter Mutations in Thai Patients with CNS WHO Grade 2 Meningiomas

OBJECTIVES: To determine the prevalence of telomerase reverse transcriptase (TERT) promoter mutations in Thai patients with atypical meningiomas and assess associations with clinical and histopathological features. MATERIALS AND METHODS: A retrospective review was conducted. Demographic, clinical, and histopathological data were collected. TERT promoter mutations were identified and analyzed for associations with features such as chordoid or clear cell variants, mitosis ≥ 4, brain invasion, necrosis, and hypercellularity. RESULTS: The cohort comprised 92 patients, 29 males and 63 females (median age 58). TERT promoter mutations were present in 5.43% of cases, most commonly C250T (60% of mutated cases). No significant associations were found between the mutation status and the assessed pathological features. CONCLUSION: TERT promoter mutations were detected in a small proportion of Thai WHO Grade 2 meningiomas. While no significant correlations with pathological features were observed, these mutations may contribute to tumor biology, warranting further study on their prognostic and therapeutic relevance.