Clausenidin from Clausena excavata Burm. causes Apoptosis of Liver Cancer in Mice

Asian Pacific Journal of Cancer Prevention 2026 Open access

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Authors: Peter Maitalata Waziri, Richard Auta, Mustapha Umar Imam, Ben A. Chindo, Zakari Ladan, Zainab Kasim Mohammed, Samson Baranzan Wayah, Jaafar Sani, Godwin Iko Ayuba, Oluwafemi T Ige, Daniel Tyoapine, Abel S Agbaji
DOI: 10.31557/apjcp.2026.27.2.481
Cited by: 0

Abstract

BACKGROUND: Clausenidin is a pyranocoumarin that was isolated from the roots of Clausena excavata Burm. Previously, the pure clausenidin crystals were successfully used to treat HepG2 cells (liver cancer) in vitro; however, no in vivo study had been conducted to support these findings. Therefore, the current study was designed to investigate the in vivo anti-liver cancer effect of pure clausenidin in hepatocellular carcinoma-induced BALB/c mice. METHOD: DNA fragmentation, caspases, and histological assays were conducted to evaluate the cytotoxic effect of the pure clausenidin, while real-time qPCR was performed to monitor the expression of apoptosis-inducing genes in the clausenidin-treated mice. RESULT: Clausenidin significantly (p

Fields of Study & Subjects

Plant chemical constituents analysis Synthesis and biological activity Flavonoids in Medical Research

Publication details

Journal / source
Asian Pacific Journal of Cancer Prevention
Volume
27
Issue
2
Pages
481–489
Publication date
1 February 2026
Language
EN