Successful Treatment of Plasmablastic Lymphoma with Daratumumab Plus CHOP: A Case Report

International Journal of Clinical Case Reports and Reviews 2026 Open access

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Authors: Youhai Yuan, Zhixiang Wang, Wejun Huang, Shanshan Zhang, Qi Wei, Xutao Guo, Ru Feng, Yongqiang Wei, Yongqiang Wei
DOI: 10.31579/2690-4861/994
Cited by: 0

Abstract

Plasmablastic lymphoma (PBL) is a rare and highly aggressive subtype of B-cell lymphoma that lacks standardized treatment. We report a 52-year-old woman who presented with back pain and lower limb weakness. Imaging and biopsy confirmed PBL involving the thoracic vertebra. The patient received daratumumab combined with CHOP chemotherapy followed by autologous stem cell transplantation and daratumumab maintenance, achieving durable complete remission for over 22 months without significant toxicity. This case highlights the potential efficacy of CD38-targeted therapy in newly diagnosed PBL and supports daratumumab plus CHOP as a feasible frontline regimen.

Fields of Study & Subjects

Viral-associated cancers and disorders Lymphoma Diagnosis and Treatment CNS Lymphoma Diagnosis and Treatment

Publication details

Journal / source
International Journal of Clinical Case Reports and Reviews
Volume
33
Issue
01
Pages
01–05
Publication date
7 January 2026