Treatment Outcome Among Patients with Atrial Fibrillation: A Systematic Review and Meta-Analysis 2025

Introduction: Due to the aging of the global population, atrial fibrillation has become the most prevalent cause of persistent cardiac arrhythmia, and is associated with significant morbidity, including stroke, heart failure, and increased mortality. Despite advances in diagnostic strategies and therapeutic options, there is variation in treatment outcomes. So this study is aimed evaluating treatment outcomes among patients with atrial fibrillation. Method and Materials: Both manual and electronic searches were used to extract studies for this meta-analysis from PubMed, Google Scholar, Scopus Web of Science, and Cochrane Library was utilized to identify the eligible articles. The identified articles were exported into EndNote software used to export, organize, and review, the eligible articles. The quality of studies was assessed by using the Joanna Briggs Institute (JBI) quality appraisal tool for prevalence study. A meta-analysis was conducted using a random-effects model in STATA Version 14 software. Result: Eleven included studies with good methodological quality and with 29, 2691participants enrolled in this study. According to this study the pooled proportion of complication was found to be 11.45% (95% CI: 7.48-15.4) and mortality 16.7% (95% CI: 10.9-22.6). The highest prevalence of complication 17.8 % (95% CI: 9.1- 26.5, I2 = 96.1%) was seen in African region, and the lowest 5.75 % (95% CI: -2.9.-14.4, I2 = 99.9%) was seen in North America region and the highest prevalence of mortality 18.6 % (95% CI: 4.1- 33.2,) was seen in African region, and the lowest 17.4 % (95% CI: 9.7. 25.1) was seen in North America region. Conclusion: This systematic review and meta-analysis found that there is a substantial burden of adverse outcomes among the studied population. So, strengthening health systems, improving early detection, and enhancing management strategies is essential to reduce complications and mortality associated with the atrial fibrillation.