Anatomical Variations of the Sphenoid Sinus in Acromegalic versus Non-Acromegalic Patients with Pituitary Adenoma: Implications for Surgical Planning

Objective: To compare the anatomical differences of the sphenoid sinus and adjacent critical structures between patients with hormone-producing pituitary tumors, distinguishing between acromegalic and non-acromegalic groups, to optimize surgical planning and anticipate potential complications.Material and Methods: A retrospective analysis was conducted on 150 patients diagnosed with hormone-secreting pituitary adenomas (50 acromegalic and 100 non-acromegalic) treated at the Neurosurgery Outpatient Clinic, Songklanagarind Hospital, between January 1, 2012 and December 31, 2022. Patient demographics and sphenoid sinus anatomical characteristics were assessed using computed tomography (CT) scans in collaboration with radiologists. Statistical analysis was performed using the R program with a significance threshold of p-value