Investigation of the Effect of Vitamin D in Severe COVID-19 Patients

ABS TRACT Objective: This study aimed to examine the effect of vitamin D on I interleukin (IL-6) and coagulation parameters in coronavirus disease-2019 (COVID-19) patients treated in the intensive care unit.Material and Methods: Two hundred and forty patients who were followed up in the intensive care unit due to severe COVID-19 infection between March 2020-April 2022 were analyzed retrospectively.The demographic characteristics of the patients and serum levels of vitamin D and interleukin (IL-6), complete blood count, troponin, pro-brain natriuretic peptide (pro-BNP), procalcitonin, D-dimer, ferritin, fibrinogen, activated partial thromboplastin time, prothrombin time, and international normalized ratio (INR) levels were analyzed.Results: Considering the groups, those with vitamin D deficiency were 79.2%, those with vitamin D insufficiency were 13.3% and those with normal vitamin D were 7.5%.There was a significant difference in age, vitamin D, cytokine measurement, prothrombin time, INR level, D-dimer, fibrinogen, platelet count, ferritin, pro-BNP, procalcitonin, and C-reactive protein (CRP) levels between the surviving and deceased patients (p