Evaluation of the Relationship Between Symptom Duration and Peripheral Blood Inflammatory Parameters in Fibromyalgia Patients

ABS TRACT Objective: Fibromyalgia syndrome (FMS) is a chronic condition whose pathophysiology has not yet been clearly established, but a correlation has been shown with inflammatory biomarkers such as C-reactive protein (CRP), and therefore, an inflammatory component is thought to play a role in its pathogenesis.The purpose of this study was to investigate the relationship between disease duration and specific inflammatory biomarkers in patients with FMS.Material and Methods: In this study, data were collected from a total of 100 patients with FMS, and the relationship between inflammation markers, such as neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, mean platelet value, platelet distribution width, CRP, and ferritin level, which can be detected by conventional complete blood count tests, was investigated.Results: A significant relationship was determined between disease duration and CRP level (p=0.027), and the CRP level was highest in the FMS group with a disease duration of 0-1 years.Conclusion: The most active period of the disease process in FMS is the first year when CRP levels are highest.Determining inflammatory activity and managing inflammation during disease follow-up may be an important goal in alleviating fibromyalgia symptoms and may highlight the potential role of anti-inflammatory approaches as a therapeutic strategy in the disease process.