Study of the pharmacological activity of a supplement based on ginsenoside of 6-year-old ginseng root against the infectious bronchitis virus of chickens

The infectious bronchitis viruses of chickens and SARS-CoV-2 are similar, therefore, the mechanism of entry of the IBD virus into the lungs through the intestine is considered as a simulation of the entry of the SARS-CoV-2 virus into the body. To conduct a laboratory experiment on the study of infectious bronchitis in chickens, Beaver cross chickens at the age of 14 days were inoculated with a 10-fold dose of the vaccine strain of infectious bronchitis in chickens. In this study, experimental birds were divided into one infected control group and two experimental groups (to evaluate the preventive and curative effectiveness of the supplement). The most pronounced pathoanatomic changes were noted in the group in which the drug was administered to the bird for therapeutic purposes. In the experimental group, in which the drug was administered before the introduction of an infectious agent (for preventive purposes), inflammatory processes were less pronounced, which may indicate the preventive effectiveness of the drug. When studying the number of viral particles, it was revealed that there was no suppression of the virus in the thymus of birds receiving the supplement for therapeutic purposes, as a result of which systemic circulation of viral particles throughout the body was observed. In the group receiving the drug for preventive purposes, through the use of a dietary supplement, the effect of the viral agent on the thymus was prevented until the virus entered the body, thereby ensuring a smoother course of coronavirus infection. An increase in the expression of proinflammatory cytokines was noted in both experimental groups. It has been established that the use of biologically active food additives “Gold of the Emperor. Immunity” causes activation of NFkB production in the thymus, lungs and intestines when the drug is used for therapeutic purposes. Application of biologically active additive “Gold of the Emperor. Immunity” caused a more intensive production of proinflammatory cytokines, however, in the case of its use for the purpose of pharmacoprophylaxis, the body’s reaction from the immune system, the course of coronavirus infection was the most favorable for the body as a whole.