Immunoexpression of stem cell markers CD44, CD133, ALDH1-2, and LGR5 in colorectal carcinoma and their association with clinicopathological tumor characteristics
Abstract
OBJECTIVE: To investigate the association of CD44, CD133, ALDH1-2, and LGR5 expression with clinicopathological tumor variables. METHODS: Twenty-eight adult patients with colorectal carcinoma who underwent curative surgery were included in the study. Paraffin-embedded samples were subjected to immunohistochemical staining with anti-CD44, anti-CD133, anti-ADLH1-2, and anti-LGR5 antibodies, and the results were compared with the patients' clinicopathological variables. P-values 60 years of age, in the rectum and right colon, and in the presence of lymph node involvement. CD44 protein expression was increased in tumors of the left colon. CONCLUSION: Increased tissue levels of ALDH1-2 and LGR5 were related to increased aggressiveness of colorectal carcinoma.
Fields of Study & Subjects
Cancer Cells and Metastasis
Proteoglycans and glycosaminoglycans research
Mesenchymal stem cell research
Publication details
- Journal / source
- Einstein (São Paulo)
- Publisher
- Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein
- Volume
- 26
- Pages
- eAO2153–eAO2153
- Publication date
- 1 January 2026
- Language
- EN