Ехосонографічна оцінка структурно-функціонального стану серця та кардіопротекторна дія кондиційованого середовища мезенхімальних стовбурових клітин при комбінованій кардіотоксичності доксорубіцину і целекоксибу

The aim – to perform an echocardiographic assessment of structural and functional cardiac alterations in combined doxorubicin- and celecoxib-induced cardiomyopathy and to determine the cardioprotective efficacy of mesenchymal stem cell-conditioned medium.Materials and methods. The study was conducted in 28 rats with experimentally induced doxorubicin- and celecoxib-associated cardiomyopathy. Echocardiographic evaluation of left ventricular morphometric, volumetric, and functional parameters was performed. The cardioprotective effects of mesenchymal stem cell–conditioned medium were compared with those of carvedilol using parametric and nonparametric statistical analyses.Results and discussion. Combined doxorubicin and celecoxib exposure resulted in marked left ventricular dilatation, with a 27.7 % increase in end-diastolic volume (p=0.049) and a 194.5 % increase in end-systolic volume (p