Genomic Analysis of Doxycycline Resistance–Associated 16S rRNA Mutations in Treponema pallidum Subspecies pallidum

Emerging infectious diseases 2026 Open access

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Authors: George S. Long, Mackenzie Neale, Thomas Braukmann, Vanessa Tran, Nishant K. Singh, Vanessa Allen, Muhammad Morshed, Jessica Minion, Paul Van Caeseele, Maud Vallée, Todd Hatchette, Samir N. Patel
+2 more RSW Tsang, Venkata R. Duvvuri
DOI: 10.3201/eid3202.251060
Cited by: 2
References: 14

Abstract

We inspected 16S rRNA sequences of 784 publicly available Treponema pallidum subspecies pallidum genomes and 17 new T. pallidum subsp. pallidum genomes from Canada for putative mutations associated with doxycycline resistance. Variants were detected in 9 non-Canada genomes. These findings establish a global genomic baseline for monitoring doxycycline resistance in syphilis.

Fields of Study & Subjects

Syphilis Diagnosis and Treatment Reproductive tract infections research Autoimmune and Inflammatory Disorders

Publication details

Journal / source
Emerging infectious diseases
Publisher
Centers for Disease Control and Prevention (CDC)
Volume
32
Issue
2
Pages
242–245
Publication date
1 February 2026
Language
EN