Acute Severe Hepatitis B Virus Infection in Previously Vaccinated Patient during Acalabrutinib Treatment

Emerging infectious diseases 2026 Open access

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Authors: Łukasz Rojek, Tomasz Wnuk-Lipinski, Iwona Marek, Hubert Grabowski, Krystian Adrych
DOI: 10.3201/eid3202.251111
Cited by: 1
References: 8

Abstract

We describe acute severe hepatitis B virus (HBV) infection with liver failure requiring transplantation in a patient in Poland treated with acalabrutinib. The patient was fully vaccinated against HBV and had adequate HBV antibody titers and no HBV exposure documented before therapy. Differential diagnoses for jaundice should consider HBV in patients receiving acalabrutunib.

Fields of Study & Subjects

Hepatitis B Virus Studies Hepatitis Viruses Studies and Epidemiology Hepatitis C virus research

Publication details

Journal / source
Emerging infectious diseases
Publisher
Centers for Disease Control and Prevention (CDC)
Volume
32
Issue
2
Pages
287–289
Publication date
1 February 2026
Language
EN