Dengue Incidence, Seroprevalence, and Expansion Factors from Active Surveillance, Brazil, 2016–2021

Emerging infectious diseases 2026 Open access

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Authors: Eliana Nogueira Castro de Barros, Manuela de Almeida Roediger, Maïna L’Azou Jackson, Morgan A. Marks, Elizabeth M. Anderson, Alejandra Esteves-Jaramillo, Germán Áñez, José María Larrañaga Moreira, Fernanda Castro Boulos
DOI: 10.3201/eid3204.250942
Cited by: 1
References: 38

Abstract

Dengue is hyperendemic in Brazil and is underestimated by passive surveillance. To better understand dengue incidence, we conducted epidemiologic analyses among participants, 2-59 years of age, from the placebo arm of a phase 3 dengue vaccine trial. During 2016-2021, a total of 5,947 participants contributed to 22,028 person-years of follow-up. We identified and virologically confirmed dengue (VCD), Zika, and chikungunya infections. We observed VCD and chikungunya incidence heterogeneity by age, geographic location, and study year. Children 2-6 years of age experienced the highest VCD (2.33/100 person-years) and chikungunya (1.02/100 person-years) incidence. VCD peaked in 2019 (n = 148) whereas chikungunya peaked in 2017 (n = 51). VCD incidence rates from active surveillance were generally higher than those reported to the national passive surveillance system; expansion factor range was

Fields of Study & Subjects

Mosquito-borne diseases and control Viral Infections and Outbreaks Research Zoonotic diseases and public health

Publication details

Journal / source
Emerging infectious diseases
Publisher
Centers for Disease Control and Prevention (CDC)
Volume
32
Issue
4
Pages
573–583
Publication date
1 April 2026
Language
EN