Review of: "The CCN Family of Proteins: A Critical Approach to the Multi-Modular Structure of the CCN Domains"

The review article "The CCN Family of Proteins: A Critical Approach to the Multi-Modular Structure of the CCN Domains" presents a comprehensive and insightful perspective on the structural and functional complexity of CCN proteins.The manuscript is authored by a highly experienced researcher in the CCN eld, and it successfully integrates historical context, structural biology, evolutionary perspectives, and functional interpretation of CCN domain organization.The review provides valuable conceptual discussion regarding domain cooperation, post-translational processing, and spatiotemporal regulatory models, which are important for understanding the multifunctional behavior of CCN proteins in cellular signaling, brosis, and tumorigenesis.The emphasis on the limitations of studying isolated domains and the advocacy for full-length protein and spatial biology approaches represents a strong and forwardlooking scienti c argument.