Hydroalcoholic Leaf Extract of Hibiscus cannabinus Restores Antioxidant Enzymes and Ameliorates HAART-Induced Hepatotoxicity in Wistar Rats
Abstract
Background: Long-term use of highly active antiretroviral therapy (HAART), typically with zidovudine, lamivudine, and nevirapine, induces hepatic oxidative stress and toxicity Objective: The antioxidant and hepatoprotective activity of hydroalcoholic leaf extract of Hibiscus cannabinus (HC) was assessed in this study against HAART-induced oxidative injury. Methods: Wistar rats were divided into three groups: Control, HAART, and HAART+HC extract. The marker levels of peroxisomal (SOD, CAT, GPx) and lipoxidative (MDA) stress were measured. Histopathological examination of the Results: HAART significantly reduced SOD, CAT, and GPx activities (p
Fields of Study & Subjects
Hibiscus Plant Research Studies
Drug-Induced Hepatotoxicity and Protection
Hops Chemistry and Applications
Publication details
- Journal / source
- International Journal of Medical and Biomedical Studies
- Volume
- 9
- Issue
- 6
- Pages
- 48–52
- Publication date
- 4 January 2026