Emerging Role of ACOD1/Itaconate in Cancer: Bridging Metabolic Reprogramming and Signaling in the Tumor Microenvironment

Biocell 2026 Open access

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Authors: Xing-Guo Li, Lu-Kai Wang, Fu‐Ming Tsai, Hsueh‐Chun Wang
DOI: 10.32604/biocell.2026.075492
Cited by: 0

Abstract

Itaconate, produced by aconitate decarboxylase 1 (ACOD1, also known as IRG1), acts as a key immunometabolite that inhibits succinate dehydrogenase (SDH) and can engage reduction-oxidation (redox)-sensitive signaling programs.... | Find, read and cite all the research you need on Tech Science Press

Fields of Study & Subjects

Immune cells in cancer Cancer Hypoxia and Metabolism Cancer Immunotherapy and Biomarkers

Publication details

Journal / source
Biocell
Volume
50
Issue
6
Pages
1–10
Publication date
1 January 2026
Language
EN