Nanoliposome-Encapsulated Semiconductor Particles and Arsenic Trioxide Synergistically Enhance Chemo-Photothermal Therapy for Lung Cancer
Abstract
Objectives: Combined chemotherapy and photothermal therapy (PTT) represents a promising approach for enhancing cancer treatment efficacy. This study aimed to develop arsenic trioxide (ATO) and poly(cyclopentadithiophene-alt-benzothiadiazole) (PCPDTBT)-loaded nanoparticles (ATO/PCPDTBT@NPs) to evaluate their synergistic efficacy in inhibiting lung cancer growth and metastasis. Methods: to monitor tumor volume reduction. Results: , the chemo-photothermal treatment reduced tumor volumes by 2.5- and 3-fold compared to ATO or PTT alone, confirming superior antitumor effects. Conclusions: These findings highlight the dual-action ATO/PCPDTBT@NPs nanoplatform as a potential multifaceted strategy for effective tumor suppression and metastasis inhibition.
Fields of Study & Subjects
Nanoplatforms for cancer theranostics
Photodynamic Therapy Research Studies
Nanoparticle-Based Drug Delivery
Publication details
- Journal / source
- Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics
- Volume
- 34
- Issue
- 4
- Pages
- 1–10
- Publication date
- 1 January 2026
- Language
- EN