Elucidating the Potential Targets and Mechanisms of Bisphenol A-Induced Prostate Cancer Based on Network Toxicology and Molecular Docking Analyses

Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics 2026 Open access

Read full text
Authors: Ashuai Du, Dianbin Guo, Dongbo Yuan, Kai Li, Yuanyuan Luo, Songsong Tan, Xuchao Dai, Bo Yu, Wanxiang You, Junjie Zhao, Bo Yan, Kehua Jiang
+2 more Xiaofei Fan, Jianguo Zhu
DOI: 10.32604/or.2026.076716
Cited by: 1

Abstract

Background: Bisphenol A (BPA) is a widely used industrial chemical and endocrine-disrupting compound, and accumulating evidence suggests that it may contribute to prostate cancer progression; however, the underlying molecular mechanisms remain incompletely elucidated. This study aimed to elucidate the molecular targets and signaling pathways underlying BPA-induced prostate cancer progression. Methods: mouse model was used to assess the impact of BPA exposure and PI3K inhibition on tumor progression. Results: . Conclusions: Collectively, these findings provide mechanistic insights into BPA-driven prostate cancer progression and highlight the value of network toxicology-based approaches in environmental toxicology research.

Fields of Study & Subjects

Effects and risks of endocrine disrupting chemicals Toxic Organic Pollutants Impact Computational Drug Discovery Methods

Publication details

Journal / source
Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics
Publisher
Tech Science Press
Volume
34
Issue
5
Pages
1–10
Publication date
1 January 2026
Language
EN