Germinal Center–Like Tertiary Lymphoid Structures Mark Immune Responsiveness and Enable Checkpoint Immunotherapy in Bladder Cancer

Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics 2026 Open access

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Authors: Zhihao Yin, Xi ZHEN, Haonan Li, Haiqiang Duan, Xiaowei Hu, Tianxi Yu, Qing Shi, Ziyi Liu, Yaowei Li, Peng Zhang, Peng Dai, Meihui Zhao
+4 more Ziqi Wang, Changfu Li, Di Wang, Zhichao Tong
DOI: 10.32604/or.2026.077808
Cited by: 1

Abstract

Together, these findings suggest that GC-like TLS maturity represents a clinically relevant biomarker and a potential therapeutic entry point for precision immunotherapy in bladder cancer. Therapeutic strategies that promote TLS maturation may convert immune-cold tumors into checkpoint-responsive states, providing a mechanistically grounded precision immunotherapy approach.

Fields of Study & Subjects

Cancer Immunotherapy and Biomarkers IL-33 ST2 and ILC Pathways Single-cell and spatial transcriptomics

Publication details

Journal / source
Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics
Publisher
Tech Science Press
Volume
34
Issue
7
Pages
1–10
Publication date
1 January 2026
Language
EN