EZH2 in Acral Lentiginous Melanoma: Molecular, Epigenetic, and Therapeutic Perspectives

Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics 2026 Open access

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Authors: Daniel Arcuschin de Oliveira, Melissa Yoshimi Sakamoto Maeda Nisimoto, Jaciara Moreira Sodré Hunnicutt, Eduarda Massa Sartori, Amanda Fáris Marques, Francisco Macedo Paschoal, Luciana Cavalheiro Marti, Miriam Galvonas Jasiulionis, Miguel Sabino Neto, Renato Santos de Oliveira Filho
DOI: 10.32604/or.2026.077913
Cited by: 1

Abstract

T-cell infiltration, and reversing transcriptional programs associated with immune resistance. This review aims to summarize the role of EZH2 in the molecular pathogenesis of ALM, emphasizing its contributions to epigenetic regulation, tumor plasticity, and immune escape, and discusses emerging therapeutic strategies targeting EZH2-mediated pathways to improve outcomes for this aggressive melanoma subtype.

Fields of Study & Subjects

Epigenetics and DNA Methylation Cutaneous Melanoma Detection and Management Glioma Diagnosis and Treatment

Publication details

Journal / source
Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics
Publisher
Tech Science Press
Volume
34
Issue
6
Pages
1–10
Publication date
1 January 2026
Language
EN