Research Progress on the Correlation between miRNA and Tamoxifen Resistance in Breast Cancer

MicroRNA (miRNA) plays a crucial regulatory role in the mechanism of tamoxifen resistance in breast cancer. This article conducts a systematic review on the molecular mechanisms, clinical significance, and potential therapeutic strategies of miRNA regulating tamoxifen resistance in breast cancer. A variety of miRNAs exert promoting or inhibitory effects on the occurrence and development of tamoxifen resistance by targeting key molecules such as the estrogen receptor signaling pathway, apoptosis-related genes, and drug transporters. These miRNAs can not only serve as biomarkers for drug resistance but also become potential therapeutic targets for reversing drug resistance. A profound understanding of the miRNA-mediated drug resistance mechanism is of great significance for improving the prognosis of breast cancer patients.