PHOSPHONATED ISOXAZOLIDINYL NUCLEOSIDES, A NEW CLASS OF MODIFIED NUCLEOSIDES

EuroMediterranean Biomedical Journal 2026 Open access

Read full text
Authors: Salvatore Vincenzo Giofrè, Roberto Romeo, Maria A. Chiacchio
DOI: 10.3269/1970-5492.2014.9.7
Cited by: 1

Abstract

This review offers an overview of the synthesis of phosphonated isoxazolidinyl nucleosides, new class of interesting and potentially antiviral/antitumor agents. The synthetic methodology relies on a 1,3-dipolar cycloaddition reaction as key step. The cycloaddition process involves substituted nitrones, phosphonated nitrones, or nitrones containing functional groups easily convertible into a phosphonated group. Biological assays are presented, which show that phosphonated isoxazolidinyl nucleosides represent new promising template of nucleoside analogues.

Fields of Study & Subjects

Chemical Synthesis and Characterization Advanced NMR Techniques and Applications Inorganic and Organometallic Chemistry

Publication details

Journal / source
EuroMediterranean Biomedical Journal
Publisher
PAGEPress Publications
Volume
9
Publication date
12 January 2026
Language
EN