IMMUNOLOGICAL ASPECTS OF CROHN’S DISEASE: A REGULATORY FUNCTION OF TIM-3/ GALECTIN-9 IN LYTH1

EuroMediterranean Biomedical Journal 2026 Open access

Read full text
Authors: F Carini, Alice Gerges Geagea, Francesca Rappa, Sabrina N. David, Giovanni Tomasello, Margherita Mazzola, Carola Maria Gagliardo, Marco Scaglione, Elena Lo Presti, Abdo R. Jurjus, Raymond Zerbe, Angelo Leone
DOI: 10.3269/1970-5492.2017.12.14
Cited by: 1

Abstract

Crohn's disease (CD) type of inflammatory bowel disease (IBD) and its etiology is multifactonal and involves a combination of genetic and environmental factors. The interaction of these factors causes an imbalance the microbiota, leading to the activation of several immunological and inflammatory mechanisms. From an immunological point of view, there seems to be an involvement of the TIM3/galectin-9 pathway and of the autoregulation of LyTh1. The studies show that in patients with CD the autoregulation of LyThl is lost due to a reduced concentration of galectin-9 and a reduced TIM-3 expression in LyThl. This could be one of the reasons the state of perpetual activation in LyTh1, resulting in the chronic inflammatory process.

Fields of Study & Subjects

Galectins and Cancer Biology Biomarkers in Disease Mechanisms

Publication details

Journal / source
EuroMediterranean Biomedical Journal
Publisher
PAGEPress Publications
Volume
12
Issue
12
Pages
66–68
Publication date
12 January 2026
Language
EN