ROLE OF HEME OXYGENASE-1 (HSP32) AND HSP90 IN GLIOBLASTOMA.

EuroMediterranean Biomedical Journal 2026 Open access

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Authors: Carlo Castruccio Castracani, Michelino Di Rosa, Pio Maria Furneri, Roberto Avola, Daniele Tibullo, Giovanni Li Volti, Francesca Rappa, Tiziana Bono
DOI: 10.3269/1970-5492.2017.12.21
Cited by: 1

Abstract

Glioblastoma (GBM) is the most common and malignant primary brain tumor in adults. The current treatment regimes for glioblastoma demonstrated a low efficiency and offer a poor prognosis.Advancements in conventional treatment strategies have only yielded modest improvements in overall survival. The heat shockproteins, heme oxygenase-1 (HO-1) and Hsp90, serve these pivotal roles in tumor cells and have been identified as effective targets for developing therapeutics. This topic review summarizes the current preclinical and clinical evidences and rationale to define the potential of HO-1 and Hsp90 in GBM progression and chemoresistance.

Fields of Study & Subjects

Heme Oxygenase-1 and Carbon Monoxide Heat shock proteins research Cancer Hypoxia and Metabolism

Publication details

Journal / source
EuroMediterranean Biomedical Journal
Publisher
PAGEPress Publications
Volume
12
Publication date
12 January 2026
Language
EN